       Document 0018
 DOCN  M9460018
 TI    Changes in longevity and causes of death among persons with hemophilia
       A.
 DT    9404
 AU    Chorba TL; Holman RC; Strine TW; Clarke MJ; Evatt BL; National Center
       for Injury Prevention and Control, Centers for; Disease Control and
       Prevention, Atlanta, Georgia 30341.
 SO    Am J Hematol. 1994 Feb;45(2):112-21. Unique Identifier : AIDSLINE
       MED/94189532
 AB    To examine recent changes in longevity and the causes of death among
       persons with hemophilia A, we evaluated death certificate data for
       persons who died in the United States from 1968 through 1989 and had
       hemophilia A or congenital Factor VIII disorder (ICD code 286.0) listed
       on the death certificate as one of the multiple causes of death.
       Multiple-cause-of-death mortality data for the United States from 1968
       to 1989 were examined to compare death rates by year, focusing on death
       rates and causes of death for 1979-1981, 1983-1985, and 1987-1989.
       Gender, age group, race, geographic region, and median age at death of
       persons with hemophilia A and human immunodeficiency virus (HIV)-related
       disease listed as a cause of death were compared with those with
       hemophilia A without HIV-related disease. From 1968 through 1989, 2,792
       hemophilia A deaths were reported. The death rate increased from 0.5 to
       1.3 per 1,000,000 persons. From 1979-1981 through 1987-1989, mortality
       increased in all age groups above 9 years of age and age at death
       shifted markedly to lower ages. Median age at death decreased from 57
       years in 1979-1981 to 40 years in 1987-1989. The percentage of deaths
       due to hemorrhage or diseases of the circulatory system decreased
       markedly as the result of the increase in deaths associated with HIV
       infection or infections other than HIV infection. Spread of HIV-1
       infection in persons with hemophilia A has disrupted the reduction in
       mortality seen with factor replacement therapy, implementation of home
       care, and use of comprehensive hemophilia treatment centers. It is hoped
       that advances in the care of HIV-infected persons will improve survival
       in the hemophilia community.
 DE    Adolescence  Adult  Aged  Aged, 80 and over  Cause of Death  Child
       Child, Preschool  Female  Hemophilia/*MORTALITY  Human  HIV
       Infections/MORTALITY  Infant  Infant, Newborn  Longevity  Male  Middle
       Age  United States  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

