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            Chronic Fatigue Syndrome Electronic Newsletter

 --------------------------------------------------------------------
 No. 36                    June 30, 1994                Washington DC
 --------------------------------------------------------------------

                    MEDICAL PUBLICATIONS UPDATE /
                    COMMENTS ON DUBLIN CONFERENCE

        CONTENTS

 >>>1.  Medical publications update
 >>>2.  Comments on Dublin Conference

NOTE:  Dr. Dedra Buchwald, M.D. is looking for a few more volunteers
for her study of identical twins where one twin has CFS and the other
does not.  Please contact her at tel. 1-206-223-3111 (leave a message
for Dr. Buchwald including a return phone number, and state that you
are calling about the "twin study").
 -------------------------------------------------------------------

 >>>1. Medical publications update

[The following was contributed by Mr. Steve Clancy, the sysop
of the Wellspring BBS which is a service of the Science Library of
the University of California at Irvine.  The material originally
submitted included citations for the January '94 special supplement
of Clinical Infectious Diseases, however these were listed in detail
in CFS-NEWS no. 32 (March 31, 1994) and so are not repeated below.]

This CFS UPDATE is a review of the current medical literature on
Chronic Fatigue Syndrome and is presented as a public service by the
Wellspring RBBS.  The presence or absence of any information in this
review should not be taken as advocating one method of treatment over
another, and should not be construed as providing medical advice or
diagnosis.

The references may be taken from various sources and should be used
for educational purposes only.  Databases accessed may include the
MEDLINE online database produced by the National Library of Medicine,
as well as other online and print sources.  This listing is NOT a
complete review, but represents a selection.  Further information may
be obtained from the U.C. Irvine, Science Library, or from your
local medical library.

STEVE CLANCY, M.L.S., WELLSPRING RBBS (714) 856-7996
                                      (714) 846-5087
                                      (714) 725-2700
                                VOICE (714) 856-7309

 (NOTE: Articles with title in brackets [ ] are not in English.)
 --------------------------------------------------------------------

1. King JC; Goddard MJ. "Pain rehabilitation: Chronic pain syndrome
and myofascial pain"  Archives of Physical Medicine and
Rehabilitation, 1994 May, 75(5 Spec No):S9-14. UID: 94241867.

2. Trojani FT. [Chronic fatigue syndrome]. Clinica Terapeutica, 1994
Mar, 144(3):269-72. UID: 94236890.

3. Trojani FT. [Chronic fatigue syndrome]. Clinica Terapeutica, 1994
Feb, 144(2):163-6. UID: 94236877.

4. Mawle AC; Reyes M; Schmid DS. "Is chronic fatigue syndrome an
infectious disease?" Infect Agents Dis, 1993 Oct, 2(5):333-41. UID:
94228156.

5. McGarry F; Gow J; Behan PO. "Enterovirus in the chronic fatigue
syndrome" [letter]. Annals of Internal Medicine, 1994 Jun 1,
120(11):972-3. UID: 94226444.

6. Hauben M. "Quinacrine and chronic fatigue syndrome" [letter].
American Family Physician, 1994 May 1, 49(6):1354. UID: 94225993.

7. Demitrack MA. "Chronic fatigue syndrome: a disease of the
hypothalamic-pituitary-adrenal axis?" [editorial]. Annals of
Medicine, 1994 Feb, 26(1):1-5. UID: 94220286.

8. Roberts L; Byrne E. "Single fibre EMG studies in chronic fatigue
syndrome: a reappraisal". Journal of Neurology, Neurosurgery and
Psychiatry, 1994 Mar, 57(3):375-6. UID: 94209963.

9. Behan WM; Behan PO. "The role of viral infection in polymyositis,
dermatomyositis and chronic fatigue syndrome". Baillieres Clin
Neurol, 1993 Nov, 2(3):637-57. UID: 94207490.

10. Manu P; Lane TJ; Matthews DA; Castriotta RJ; Watson RK; Abeles M.
"Alpha-delta sleep in patients with a chief complaint of chronic
fatigue". Southern Medical Journal, 1994 Apr, 87(4):465-70. UID:
94204795.

11. Berg PA; Klein R. [The fibromyalgia syndrome. A
neuroendocrinological autoimmune disease?]. Deutsche Medizinische
Wochenschrift, 1994 Mar 25, 119(12):429-35. UID: 94192457.

12. MacLean G; Wessely S. "Professional and popular views of chronic
fatigue syndrome". Bmj, 1994 Mar 19, 308(6931):776-7. UID: 94191461.

13. Pawlikowska T; Chalder T; Hirsch SR; Wallace P; Wright DJ;
Wessely SC. "Population based study of fatigue and psychological
distress". Bmj, 1994 Mar 19, 308(6931):763-6. UID: 94191458.

14. Wilson A; Hickie I; Lloyd A; Hadzi-Pavlovic D; Boughton C; Dwyer
J; Wakefield D. "Longitudinal study of outcome of chronic fatigue
syndrome". Bmj, 1994 Mar 19, 308(6931):756-9. UID: 94191453.

15. Lawrie SM; Pelosi AJ. "Chronic fatigue syndrome: prevalence and
outcome" [editorial; comment]. Bmj, 1994 Mar 19, 308(6931):732-3.
UID: 94191446.

16. Schwartz RB; Komaroff AL; Garada BM; Gleit M; Doolittle TH; Bates
DW; Vasile RG; Holman BL. "SPECT imaging of the brain: comparison of
findings in patients with chronic fatigue syndrome, AIDS dementia
complex, and major unipolar depression"  Ajr. American Journal of
Roentgenology, 1994 Apr, 162(4):943-51.

17. Schwartz RB; Garada BM; Komaroff AL; Tice HM; Gleit M; Jolesz FA;
Holman BL.  "Detection of intracranial abnormalities in patients with
chronic fatigue syndrome: comparison of MR imaging and SPECT."  Ajr.
American Journal of Roentgenology, 1994 Apr, 162(4):935-41. UID:
94189426.

18. Saisch SG; Deale A; Gardner WN; Wessely S. "Hyperventilation and
chronic fatigue syndrome." Quarterly Journal of Medicine, 1994 Jan,
87(1):63-7. UID: 94188484.

19. Natelson BH; Cohen JM; Brassloff I; Lee HJ. "A controlled study
of brain magnetic resonance imaging in patients with the chronic
fatigue syndrome"  Journal of the Neurological Sciences, 1993 Dec 15,
120(2):213-7. UID: 94186821.

20. Clee MD; McLaughlin K. "Complications of sarcoidosis. Chronic
fatigue syndrome [letter]."  Sarcoidosis, 1993 Sep, 10(2):138. UID:
94188589

21. Dakin G.  "Chronic illness: me and you and me" Nursing Times,
1993 Aug 25-31, 89(34):38-41. UID: 94188156

22. Roulet Perez E; Maeder P; Cotting J; Eskenazy-Cottier AC; Deonna
T. "Acute fatal parainfectious cerebellar swelling in two children. A
rare or an overlooked situation?"  Neuropediatrics, 1993 Dec,
24(6):346-51. UID: 94181121

23. McDonald E; David AS; Pelosi AJ; Mann AH. "Chronic fatigue in
primary care attenders" Psychological Medicine, 1993 Nov,
23(4):987-98. UID: 94181722

24. Bialyszewski A. [The chronic fatigue syndrome]. Psychiatria
Polska, 1993 Nov-Dec, 27(6):601-11. UID: 94181694

25. James DG. "Complications of sarcoidosis. Chronic fatigue syndrome
[editorial]"  Sarcoidosis, 1993 Mar, 10(1):1-3.  UID: 94181934

26. Auger PL; Gourdeau P; Miller JD. "Clinical experience with
patients suffering from a chronic fatigue-like syndrome and repeated
upper respiratory infections in relation to airborne molds"  American
Journal of Industrial Medicine, 1994 Jan, 25(1):41-2. UID: 94161029

27. Komaroff AL; Bell DS; Cheney PR; Lo SC. "Absence of antibody to
Mycoplasma fermentans in patients with chronic fatigue syndrome
[letter]"  Clinical Infectious Diseases, 1993 Dec, 17(6):1074-5. UID:
94154119

28. Ogawa R. [Chronic fatigue symptom]  Kango, 1993 Apr,
45(4):159-68. UID: 94150067

29. Natelson BH; Ye N; Moul DE; Jenkins FJ; Oren DA; Tapp WN; Cheng
YC. "High titers of anti-Epstein-Barr virus DNA polymerase are found
in patients with severe fatiguing illness"  Journal of Medical
Virology, 1994 Jan, 42(1):42-6. UID: 94141478

30.  Rebora A; Drago F. "Chronic fatigue syndrome: a novel disorder
with cutaneous manifestations"  Dermatology, 1994, 188(1):3-5. UID:
94138104

31. Bates DW; Schmitt W; Buchwald D; Ware NC; Lee J; Thoyer E;
Kornish RJ; Komaroff AL. "Prevalence of fatigue and chronic fatigue
syndrome in a primary care practice"  Archives of Internal Medicine,
1993 Dec 27, 153(24):2759-65. UID: 94079490

32. Jason LA; Taylor SL; Johnson S; Goldston SE; Salina D; Bishop P;
Wagner L. "Prevalence of chronic fatigue syndrome-related symptoms
among nurses"  Evaluation and the Health Professions, 1993 Dec,
16(4):385-99. UID: 94085438

33. McLaughlin B. "Virology laboratory diagnosis of chronic fatigue
syndrome"  Canada Diseases Weekly Report, 1991 Jan, 17 Suppl 1E:51-5.
UID: 94074004

34. Richman JA; Flaherty JA; Rospenda KM. "Chronic fatigue syndrome:
have flawed assumptions been derived from treatment-based studies?"
American Journal of Public Health, 1994 Feb, 84(2):282-4. UID:
94127641

35. Shepherd C. "Chronic fatigue syndrome or myalgic encephalitis
[letter]"  Lancet, 1994 Jan 22, 343(8891):243. UID: 94118689

36. Howes S. "Chronic fatigue syndrome or myalgic encephalitis
[letter]"  Lancet, 1994 Jan 22, 343(8891):243. UID: 94118688

37. Arber M; Macintyre A. "Chronic fatigue syndrome or myalgic
encephalitis [letter]" Lancet, 1994 Jan 22, 343(8891):242-3. UID:
94118687

38. Honda M; Kitamura K; Nakasone T; Fukushima Y; Matsuda S; Nishioka
K; Matsuda J; Hashimoto N; Yamazaki S. "Japanese patients with
chronic fatigue syndrome are negative for known retrovirus
infections"  Microbiology and Immunology, 1993, 37(10):779-84. UID:
94118907

39. Blondel-Hill E; Shafran SD. "Treatment of the chronic fatigue
syndrome. A review and practical guide"  Drugs, 1993 Oct,
46(4):639-51. UID: 94109295

40. Mossin S. [Diffuse suffering. Suspect behavior of patients with
illness without objective medical findings]  Sykepleien Fag, 1993 Dec
7, 81(6):3-6. UID: 94101008

41. Young A. "Amma therapy: a holistic approach to chronic fatigue
syndrome"  Journal of Holistic Nursing, 1993 Jun, 11(2):172-82. UID:
94103595

42. Morris DH; Stare FJ. "Unproven diet therapies in the treatment of
the chronic fatigue syndrome"  Archives of Family Medicine, 1993 Feb,
2(2):181-6. UID: 94101089

43. Raik E. "Chronic fatigue syndrome and the medical referee
[letter]"  Medical Journal of Australia, 1994 Jan 3, 160(1):47-8.
UID: 94097268

44. Howland RH. "General health, health care utilization, and medical
comorbidity in dysthymia"  International Journal of Psychiatry in
Medicine, 1993, 23(3):211-38. UID: 94095307

45. Camus F; Henzel D; Janowski M; Raguin G; Leport C; Vilde JL.
"Unexplained fever and chronic fatigue: abnormal circadian
temperature pattern"  European Journal of Medicine, 1992 Apr,
1(1):30-6. UID: 94093849

46. Aoki T; Miyakoshi H; Usuda Y; Herberman RB. "Low NK syndrome and
its relationship to chronic fatigue syndrome"  Clinical Immunology
and Immunopathology, 1993 Dec, 69(3):253-65. UID: 94062160

47. Kitani T. [Chronic fatigue syndrome]  "Nippon Naika Gakkai
Zasshi. Journal of Japanese Society of Internal Medicine, 1993 Sep
10, 82(9):1571-6. UID: 94065413

48. David A; Wessely S. "Chronic fatigue, ME, and ICD-10 [letter]"
Lancet, 1993 Nov 13, 342(8881):1247-8. UID: 94048692

49. Lerner AM; Lawrie C; Dworkin HS. "Repetitively negative changing
T waves at 24-h electrocardiographic monitors in patients with the
chronic fatigue syndrome. Left ventricular dysfunction in a cohort"
Chest, 1993 Nov, 104(5):1417-21. UID: 94038152

50. Chalder T; Deale A. "Don't dismiss exercise [letter]" Nursing
Times, 1993 Oct 20-26, 89(42):22-3. UID: 94051703

51. Fucikova T; Petanova J. [Chronic fatigue syndrome]  Vnitrni
Lekarstvi, 1993 Oct, 39(10):995-1002. UID: 94055139

52. Schwartz JE; Jandorf L; Krupp LB. "The measurement of fatigue: a
new instrument"  Journal of Psychosomatic Research, 1993 Oct,
37(7):753-62. UID: 94046722

53. Mathieson A. "Myalgic encephalomyelitis: continuing the debate"
Nursing Standard, 1993 Sep 22-28, 8(1):20-1. UID: 94031638

54. Chester AC. "Symptom relief after endoscopic sinus surgery: an
outcomes-based study [letter]" Ear, Nose, and Throat Journal, 1993
Sep, 72(9):633; discussion 634. UID: 94038736

55. Pietrewicz M. [A case of infectious mononucleosis syndrome caused
by cytomegalovirus]  Przeglad Epidemiologiczny, 1993, 47(3):313-6.
UID: 94052767


 -=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-

 >>>2.  Comments on Dublin Conference

An International Conference on Chronic Fatigue was held on May 18
through 20, 1994 in Dublin, Ireland.  Several participants recently
offered comments to CFS-NEWS about the conference.  Few things that
were genuinely new were presented at the conference, although many of
the presentations were being heard for the first time by the largely
European audience.  Some medical professionals who attended have said
that some of the most interesting portions were those things that
came up during the discussion sessions rather than in the formal
presentations.  (These discussions are equally referred to in the
descriptions below.)  Many Europeans drew encouragement from the
event and felt overall a sense of legitimization for the illness that
hadn't been present at other conferences they had attended.

Dr. Juan Carlos De La Torre (Scripps Research Center, La Jolla,
California) discussed animal evidence that some viruses may exist
indefinitely inside of cells without causing inflammation or necrosis
(cell death) but which may nonetheless affect cell metabolism and be
virtually undetectable otherwise.  Some work was described which
showed that vaccinations are not a trigger for CFS, however Dr.
Charles Shepherd found this evidence unconvincing and he commented to
CFS-NEWS that he was standing by the previous work to the contrary
done by himself and Dr. Byron Hyde.  Dr. Marinos Dalakas (NIH) spoke
about parallels between CFS and post-polio syndrome.  Dr. Anthony
Komaroff discussed SPECT and MRI scans, and definitional issues.
There were presentations on muscle dysfunction, some confirmatory of
earlier work but others not.  Dr. Mark Demitrack discussed HPA
involvement.  Dr. MacGregor of Australia spoke about a fish toxin
which apparently induced symptoms of CFS/ME.

Dr. Swinburne of Leeds and Dr. Wilhemina Behan of Glasgow described
findings of phosphate depletion associated with ATP abnormalities,
and mitochondrial dysfunction.  Prof. John Hughes of Cambridge
discussed the neurotransmitter CCK which he found in excessive levels
in CFS patients, which would prompt oversensitivity to pain as well
as other symptoms.  Prof. Hughes said he was searching for a CCK
suppressor which might be a potential treatment.

Regarding treatments, there was some discussion about carnitine
supplements by Dr. Kuratsume from Japan, as well as a finding that
acyl-carnitine levels correlate to severity of symptoms.  Dr. E.C.
Bergman of South Africa spoke about the use of ETDA, a chelation of
calcium.  There were also reports about the development of several
program centers that provide assistance specifically for CFS/ME
patients.

CFS-NEWS expects to publish a more detailed report in the near future
from one of the participants of the conference.

[Many thanks to Doctors Ann MacIntyre, Charles Shepherd, and Charles
Lapp for sharing their impressions with CFS-NEWS.  Thanks also to Dr.
Ellen Goudsmit, PhD. of IFMEA, Vicky Carpman, editor of the CFIDS
Chronicle, and Leslie Boyer for special assistance.]


 ===================================================================
 CFS-NEWS (ISSN 1066-8152) is an international newsletter published
 and edited by Roger Burns in Washington D.C.  It is distributed:
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