DISOPYRAMIDE BRAND NAMES Norpace Rythmodan Norpace CR Rythmodan-LA BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Antiarrhythmic USES Corrects heart rhythm disorders. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. When to take: At the same times each day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Delays nerve impulses to heart to regulate heartbeat. Time lapse before drug works: Begins in 30 to 60 minutes. Must use for 5 to 7 days to determine effectiveness. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do Life-threatening: None expected. Common: Hypoglycemia Discontinue. Call doctor right away. Dry mouth, constipation, Continue. Call doctor painful or difficult when convenient. urination, rapid weight gain. Infrequent: Dizziness, fainting, Discontinue. Call doctor confusion, nervousness, right away. depression, chest pain, slow or fast heartbeat. Swollen feet. Continue. Call doctor when convenient. Rare: Sore throat with Discontinue. Call doctor fever, jaundice. right away. Eye pain, diminished Continue. Call doctor sex drive. when convenient. OVERDOSE Symptoms: Blood-pressure drop, irregular heartbeat. What to do: *Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. *If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. *See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to disopyramide or any antiarrhythmic. You have second- or third-degree heart block. Before you start, consult your doctor: If you react unfavorably to other antiarrhythmic drugs. If you have had heart disease. If you have low blood pressure. If you have liver disease. If you have glaucoma. If you have enlarged prostate. If you have myasthenia gravis. If you take digitalis preparations or diuretics. Over age 60: May require reduced dose. More likely to have difficulty urinating or be constipated. More likely to have blood-pressure drop. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Safety not established. Don't use. Prolonged use: No problems expected. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics, or mind-altering drugs. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: If new illness, injury or surgery occurs, tell doctors of disopyramide use. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Ambenonium Decreased ambenonium effect. Anticholinergics Increased anticholinergic effect. Anticoagulants (oral) Increased anticoagulant effect. Antihypertensives Increased antihypertensive effect. Antimyasthenics Decreased antimyasthenic effect. Flecainide Possible irregular heartbeat. Tocainide Increased likelihood of adverse reactions with either drug. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Decreased blood pressure and blood sugar. Use caution. Beverages None expected. Cocaine Irregular heartbeat. Foods None expected. Marijuana Unpredictable. May decrease disopyramide effect. Tobacco May decrease disopyramide effect. PROPRANOLOL BRAND NAMES Apo-Propranolol Inderide Detensol Novopranol Inderal Panolol Inderal LA pms-Propranolol BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Beta-adrenergic blocker USES .Reduces angina attacks. .Stabilizes irregular heartbeat. .Lowers blood pressure. .Reduces frequency of migraine headaches. (Does not relieve headache pain.) .Other uses prescribed by your doctor. DOSAGE & USAGE INFORMATION How to take: Tablet, liquid or extended-release capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. Don't crush capsule. When to take: With meals or immediately after. If you forget a dose: Take as soon as you remember. Return to regular schedule, but allow 3 hours between doses. What drug does: .Blocks certain actions of sympathetic nervous system. .Lowers heart's oxygen requirements. .Slows nerve impulses through heart. .Reduces blood vessel contraction in heart, scalp and other body parts. Time lapse before drug works: 1 to 4 hours. Don't take with: Non-prescription drugs or drugs in interaction column without consulting doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do ___________________________________________________________________ Life-threatening: Congestive heart failure. Discontinue. Seek emergency treatment. Common: .Pulse slower than 50 Discontinue. Call doctor beats per minute. right away. .Drowsiness, fatigue, Continue. Call doctor numbness or tingling when convenient. of fingers or toes, dizziness, diarrhea, nausea, weakness. .Cold hands or feet; Continue. Tell doctor dry mouth, eyes and at next visit. skin. Infrequent: .Hallucinations, Discontinue. Call doctor nightmares, insomnia, right away. headache, difficult breathing, joint pain, anxiety. .Confusion, reduced Continue. Call doctor when alertness, depression, convenient. impotence. .Constipation. Continue. Tell doctor at next visit. Rare: .Rash, sore throat, Discontinue. Call doctor fever. right away. .Unusual bleeding and Continue. Call doctor when bruising; dry, burning convenient. eyes; impotence. OVERDOSE Symptoms: Weakness, slow or weak pulse, blood-pressure drop, fainting, difficulty breathing, convulsions, cold and sweaty skin. What to Do: .Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. .See emergency information. WARNINGS AND PRECAUTIONS Don't take if: .You are allergic to any beta-adrenergic blocker. .You have asthma. .You have hay fever symptoms. .You have taken MAO inhibitors in past 2 weeks. Before you start, consult your doctor: .If you have heart disease or poor circulation to the extremities. .If you have hay fever, asthma, chronic bronchitis, emphysema. .If you have overactive thyroid function. .If you have impaired liver or kidney function. .If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. .If you have diabetes or hypoglycemia. Over age 60: Adverse reactions and side effects may b emore frequent and severe than in younger persons. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Not recommended. Prolonged use: Weakens heart muscle contractions. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment. Others: May mask hypoglycemia. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect _______________________________________________________________________ ACE inhibitors: Increased antihypertensive captopril, enalapril, effects of both drugs. lisinopril Dosages may require adjustment. Antidiabetics Increased antidiabetic effect. Antihistamines Decreased antihistamine effect. Antihypertensives Increased antihypertensive effect. Barbiturates Increased barbiturate effect. Dangerous sedation. Beta-agonists Decreased beta-agonist effect. Betaxolol eyedrops Possible increased propronalol effect. Digitalis preparations Can either increase or decrease heart rate. Improves irregular heartbeat. Encainide Increased effect of toxicity on heart muscle. Indomethacin Decreased effect of propranolol. Insulin Hypoglycemic effects may be prolonged. Levobunolol eyedrops Possible increased propranolol effect. Molindone Increased tranquilizer effect. Narcotics Increased narcotic effect. Dangerous sedation. Nitrates Possible excessive blood-pressure drop. Non-steroidal Decreased antihypertensive effect anti-inflammatory of propranolol. drugs (NSAIDS) Phenytoin Decreased propranolol effect. Quinidine Slows heart excessively. Reserpine Increased reserpine effect. Excessive sedation and depression. Rifampin Decreased propranolol effect. Timolol eyedrops Possible increased propranolol effect. Tocainide May worsen congestive heart failure. Verapamil Increased effect of both drugs. _______________________________________________________________________ POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined effect _______________________________________________________________________ Alcohol Excessive blood-pressure drop. Avoid. Beverages None expected. Cocaine Irregular heartbeat. Avoid. Foods None expected. Marijuana Daily use--impaired circulation to hands and feet. Tobacco Possible irregular heartbeat. ISOXSUPRINE BRAND NAMES Vasodilan Vasoprine BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Vasodilator USES Improves poor blood circulation. DOSAGE AN USAGE INFORMATION How to take: Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. When to take: At the same times each day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Expands blood vessels, increasing flow and permitting distribution of oxygen and nutrients. Time lapse before drug works: 1 hour. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Appetite loss, nausea, Discontinue. Call doctor vomiting. right away. Dizziness, faintness. Continue. Call doctor when convenient. Weakness, lethargy. Continue. Tell doctor at next visit. Infrequent: Rash. Discontinue. Call doctor right away. Rare: Rapid or irregular Discontinue. Call doctor heartbeat. right away. OVERDOSE Symptoms: Headache, dizziness, flush, vomiting, weakness, sweating, fainting, shortness of breath, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any vasodilator. You have any bleeding disease. Before you start, consult your doctor: If you have high blood pressure, hardening of the arteries or heart disease. If you plan to become pregnant within medication period. If you have glaucoma. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: Studies inconclusive on harm to unborn child. Decide with your doctor whether drug benefits justify risk to unborn child. Breast-feeding: No problems expected, but consult doctor. Infants and children: Not recommended. Prolonged use: No problems expected. Skin and sunlight: No problems expected, Driving, piloting or hazardous work: Avoid if you feel dizzy or faint. Otherwise, no problems expected. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: Be cautious when arising from lying or sitting position, when climbing stairs, or if dizziness occurs. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect None POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol None expected. Beverages Decreased stomach Milk irritation. Cocaine Decreased blood circulation to extremities. Avoid. Foods None expected. Marijuana Rapid heartbeat. Tobacco Decreased isoxsuprine effect. NITRATES BRAND NAMES: Ang-O-Span, Cardilate, Coronex, Dilatrate-SR, Duotrate, The following are listed under their generic names (in capitals). ERYTHRITYL TETRANITRATE ISOSORBIDE DINITRATE Glyceryl Trinitrate Isotrate Iso-Bid Kaytrate Isochron Klavikordal Isogard Naptrate Isonate N-G-C Isonate TR Niong Isordil Nitro-Bid Nitrobon NITROGLYCERIN Nitrocap Nitroglyn Nitrocap T.D. Nitrol Nitrocardin Nitrolin Nitrodisc Nitro-Long Nitro-Dur Nitronet Nitrogard-SR Nitrong Nitrospan Nitrostablin Nitrostat Nitro-Time Novosorbide Onset PENTAERYTHRITOL TETRANITRATE Pentestan Pentol Pentol S.A. Pentraspan Pentraspan SR Pentritol Pentylan Peritrate Peritrate SA P.E.T.N. Sorate Sorbide Sorbide T.D. Sorbitrate Sorbitrate SA Susadrin Tranderm-Nitro Trates Tridil Vaso-80 Vasoglyn BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Antianginal (nitrate) USES Reduces frequency and severity of angina attacks. DOSAGE AND USAGE INFORMATION How to take: *Extended-release tablets or capsules Swallow each dose whole with liquid. *Chewable tablet Chew tablet at earliest sign of angina, and hold in mouth for 2 minutes. *Regular tablet or capsule Swallow whole with liquid. Don't crush, chew or open. *Ointment Apply as directed. *Sublingual tablets Place under tongue every 3 to 5 minutes at earliest sign of angina. If you don't have complete relief with 3 or 4 tablets, call doctor. When to take: *Swallowed tablets Take at the same times each day, 1 or 2 hours after meals. *Ointment Follow prescription directions. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Relaxes blood vessels, increasing blood flow to heart muscle. Time lapse before drug works: *Sublingual tablets 1 to 3 minutes. *Other forms 15 to 30 minutes. Will not stop an attack, but may prevent attacks. OVERDOSE Symptoms: Dizziness; blue fingernails and lips; fainting; shortness of breath; weak, fast heartbeat; convulsions. What to do: *Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. *See section on emergency information. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do Life-threatening: None expected. Common: Headache, flushed Continue. Tell doctor face and neck, dry at next visit. mouth, nausea, vomiting, rapid heartbeat. Infrequent: Fainting Discontinue. Call doctor right away. Restlessness, Continue. Call doctor Blurred vision. when convenient. Rare: Rash Discontinue. Call doctor right away. Severe irritation, Continue. Call doctor peeling. when convenient. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to nitrates, including nitroglycerin. Before you start, consult your doctor: If you are taking non-prescription drugs. If you plan to become pregnant within medication period. If you have glaucoma. If you have reacted badly to any vasodilator drug. If you drink alcoholic beverages or smoke marijuana. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: No problems expected. Consult your doctor. Infants and children: Not recommended. Prolonged use: Drug may become less effective and require higher doses. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Except for sublingual tablets, don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: If discomfort is not caused by angina, nitrate medication will not bring relief. Call doctor id discomfort persists. Periodic urine and laboratory blood studies of white cell counts recommended if you take nitrates. Keep sublingual tablets in original container. Always carry them with you, but keep from body heat if possible. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticholinergics Increased internal-eye pressure. Antidepressants Excessive blood-pressure (tricyclics) drop. Antihypertensives Excessive blood-pressure drop. Cholinergics Decreased cholinergic effect. Ephedrine Decreased nitrate effect. Labetolol Increased antihypertensive effects. Narcotics Excessive blood-pressure drop POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Excessive blood-pressure drop Beverages None expected. Cocaine Flushed face and headache. Avoid. Marijuana Decreased nitrate effect. Tobacco Decreased nitrate effect. NIFEDIPINE BRAND NAMES Adalat Procardia BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? No Drug class: Calcium-channel blocker, antiarrhythmic, antianginal. USES .Prevents angina attacks. .Treats Reynaud's disease. .Treats high blood pressure. .Treats spasm of the esophagus. DOSAGE AND USAGE INFORMATION How to take: Capsule or extended-release tablet--Swallow with liquid. When to take: At the same times each day 1 hour before or 2 hours after eating. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: .Reduces work that heart must perform. .Reduces normal artery pressure. .Increases oxygen to heart muscle. Time lapse before drug works: 1 to 2 hours. Don't take with: See Interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do _______________________________________________________________________ Life-threatening: None expected. Common: Tiredness, flushing, Continue. Tell doctor swelling of feet, at next visit. ankles and abdomen. Infrequent: .Unusually fast or Discontinue. Call unusually slow doctor right away. heartbeat, wheezing, cough, shortness of breath. .Dizziness; numbness Continue. Call doctor or tingling in hands when convenient. or feet; swelling of ankles, feet, legs; difficult urination. .Nausea Continue. Tell doctor constipation. at next visit. Rare: .Transient blindness, Discontinue. Seek increased angina. emergency treatment. .Fainting, chest pain, Discontinue. Call fever, rash, jaundice, doctor right away. depression, psychosis. .Arthritis, hair loss. Continue. Call doctor vivid dreams. when convenient. .Headache. Continue. Tell doctor at next visit. OVERDOSE Symptoms: Unusually fast or unusually slow heartbeat, loss of consciousness, cardiac arrest. What to do: .Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. .If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. .See emergency information. WARNINGS AND PRECAUTIONS Don't take if: .You are allergic to nifedipine. .You have very low blood pressure. Before you start, consult your doctor: .If you have kidney or liver disease. .If you have high blood pressure. .If you have heart disease other than coronary-artery disease. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: Safety not established. Avoid if possible. Infants and children: Not recommended. Prolonged use: No problems expected. Skin and sunlight: Increased sensitivity to sunlight. Driving, piloting or hazardous work: Avoid if you feel dizzy. Otherwise, no problems expected. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: .Learn to check your own pulse rate. If it drops to 50 beats per minute or lower, don't take nifedipine until you consult your doctor. .Drug may lower blood-sugar level if daily dose is more than 60 mg. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined effect _______________________________________________________________________ ACE inhibitors: Possible excessive captopril, enalapril, potassium in blood. lisinopril Dosages may need adjustment. Antiarrhythmics Possible increased effect and toxicity of each drug. Anticoagulants Possible increased (oral) anticoagulant effect. Anticonvulsants Increased (hydantoin) anticonvulsant effect. Antihypertensives Dangerous blood pressure drop. Dosage may need adjustment. Beta-adrenergic Possible irregular heartbeat. blockers May worsen congestive heart failure. Calcium Possible decreased nifedipine (large doses) effect. Carbamazepine May increase carbamazepine effect and toxicity. Cimetidine Possible increased nifedipine effect and toxicity. Disopyramide May cause dangerously slow, fast or irregular heartbeat. Diuretics Dangerous blood pressure drop. Lithium Possible decreased lithium effect. Nitrates Reduced angina attacks. Phenytoin Possible decreased nifedipine effect. Quinidine Increased quinidine effect. Rifampin Decreased nifedipine effect. Theophylline May increase theophylline effect and toxicity. Tocainide Increased likelihood of adverse reactions from either drug. Vitamin D Decreased nifedipine effect. (large doses) _______________________________________________________________________ POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined effect _______________________________________________________________________ Alcohol: Dangerously low blood pressure. Avoid. Beverages: None expected. Cocaine: Possible irregular heartbeat. Avoid. Foods: None expected. Marijuana: Possible irregular heartbeat. Avoid. Tobacco: Possible rapid heartbeat. Avoid. METHYSERGIDE BRAND NAMES Sansert BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? No Drug class: Vasoconstrictor (antiserotonin) USES Prevents migraine and other recurring vascular headaches. Not for acute attack. DOSAGE AND USAGE INFORMATION How to take: Tablet--Swallow with liquid or with food to lessen stomach irritation. If you can't swallow whole, crumble tablet and take with liquid or food. When to take: At the same times each day. If you forget a dose: Don't take missed dose. Wait for next scheduled dose (DON'T double this dose). What drug does: Blocks the action of serotonin, a chemical that constricts blood vessels. Time lapse before drug works: About 3 weeks. Don't take with: See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do _________________________________________________________________________ Life-threatening: None expected Common: .Itchy skin. Discontinue. Call doctor right away. .Nausea, vomiting, Continue. Call doctor when diarrhea, numbness convenient. or tingling of extremities. .Drowsiness, Continue. Tell doctor at next visit. constipation. Infrequent: .Anxiety, agitation, Discontinue. Call doctor right away. hallucinations, unusually fast or slow heartbeat. .Change in vision. Continue. Call doctor when convenient. Rare: .Extreme thirst, chest Discontinue. Call doctor right away. pain, shortness of breath, fever, pale or swollen extremities, leg cramps, lower back pain, side or groin pain. appetite loss, joint and muscle pain, rash, facial flush. .Painful or difficult Continue. Call doctor when convenient. urination. .Weight change, Continue. Tell doctor at next visit. hair loss, swollen feet and ankles. _____________________________________________________________________________ OVERDOSE Symptoms: Nausea, vomiting, abdominal pain, severe diarrhea, lack of coordination, extreme thirst. What to do: Overdose unlikely to threaten life. If person takes much larger amount than prescribed, call doctor, poison-control center or hospital emergency room for instructions. WARNINGS AND PRECAUTIONS Don't take if: .You are allergic to any antiserotonin. .You plan to become pregnant within medication period. .You have an infection. .You have a heart or blood-vessel disease. .You have a chronic lung disease. .You have a collagen (connective tissue) disorder. .You have impaired liver or kidney function. Before you start, consult your doctor: .If you have been allergic to any ergot preparation. .If you have had a peptic ulcer. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: Manufacturer suggests risk to unborn child outweighs drug benefits, even though studies are inconclusive. Breast-feeding: Drug probably passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Not recommended. Prolonged use: Possible fibrosis, a condition in which scar tissue is deposited on heart valves, in lung tissue, blood vessels and internal organs. After 6 months, decrease dose over 2 to 3 weeks. Then discontinue for at least 2 months for re- evaluation. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Avoid if you feel drowsy or dizzy. Otherwise, no problems expected. Discontinuing: .Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. doses of other drugs may also require adjustment. .Probably should discontinue drug if you don't improve after 3 weeks' use. Others: .Periodic laboratory tests for liver function and blood counts recommended. .Potential for abuse. .Some products contain tartrazine dye. Avoid, especially if you are allergic to aspirin. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect _________________________________________________________________________ Ergot Preparations Unpredictable increased or decreased effect of either drug. Narcotics Decreased narcotic effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined effect _________________________________________________________________________ Alcohol: None expected. However, alcohol may trigger a migraine headache. Beverages: Caffeine drinks. Decreased methysergide effect. Cocaine: May make headache worse. Foods: None expected. Avoid foods to which you are allergic. Marijuana: No proven problems. Tobacco: Blood-vessel constriction. Makes headache worse. Downloaded From P-80 International Information Systems 304-744-2253