ÕÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ͸ ³ ³ ³ ------Cardiac and Circulatory------ ³ ³ ³ ³ A. Digitalis Preparations ³ ³ B. Dipyridamole ³ ³ C. Disopyramide ³ ³ D. Inderal ³ ³ E. Isoxsuprine ³ ³ F. Nitrates ³ ³ G. Procardia ³ ³ H. Sansert ³ ³ ³ ÔÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ; DIGITALIS PREPARATIONS BRAND AND GENERIC NAMES (Generic name in capitals) Crystodigin Gitaligen Crystogin GITALIN Digifortis Lanoxicaps Digiglusin Lanoxin DIGITALIS Natigozine DIGITOXIN Novodigoxin DIGOXIN Purodigin BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Digitalis preparations USES Strengthens weak heart-muscle contractions to prevent congestive heart failure. Corrects irregular heartbeat. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid. If you can't swallow shole, crumble tablet or open capsule and take with liquid or food. Liquid--Dilute dose in beverage before swallowing. When to take: At the same time each day. If you forget a dose: Take as soon as you remember up to 12 hours late. If more than 12 hours, wait for next scheduled dose (don't double this dose). What drug does: Strengthens heart-muscle contraction. Delays nerve impulses to heart. Time lapse before drug works: May require regular use for a week or more. Don't take with: Non-prescription drugs without consulting doctor. See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected Common: Appetite loss, diarrhea Continue. Call doctor when convenient. Infrequent: Drowsiness, lethargy, Discontinue. Call doctor disorientation. right away. Rare: Rash, hives Discontinue. Call doctor right away. Double or yellow- Continue. Call doctor green vision; when convenient. enlarged, sensitive male breasts; tiredness; weakness. OVERDOSE Symptoms: Nausea, vomiting, diarrhea, vision disturbances with halos around lights, irregular heartbeat, confusion, hallucinations, convulsions. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any digitalis preparation. Your heartbeat is slower than 50 beats per minute. Before you start, consult your doctor: If you have taken another digitalis preparation in past 2 weeks. If you have taken a diuretic within 2 weeks. If you have liver or kidney disease. If you have a thyroid disorder. If you will have surgery within 2 months, including dental surgery, requiring general of spinal anesthesia. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: Studies inconclusive on harm to unborn child. Consult your doctor. Breast-feeding: Drug filters into milk. May harm child. Avoid. Infants and children: Use only under medical supervision. Prolonged use: No problems expected. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Possible vision disturbances. Otherwise, no problems expected. Discontinuing: Don't stop without doctor's advice. Others: No problems expected. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Class of Drugs Combined Effect Albuterol Increased risk of heartbeat irregularity. Amiodarone Increased digitalis effect. Antacids Decreased digitalis effect. Anticonvilsants Increased digitalis (hydantoin) effect at first, then decreased. Beta-adrenergic blockers Increased digitalis effect. Calcium supplements Decreased digitalis effect. Cortisone drugs Digitalis toxicity. Diuretics Possible digitalis toxicity. Ephedrine Disturbed heart rhythm. Avoid. Epinephrine Disturbed heart rhythm. Avoid. Flecainide May increase digitalis blood level. Guanethidine Increased digitalis effect. Indapamide Excessive potassium loss that may cause irregular heartbeat. Laxatives Decreased digitalis effect. Oxyphenbutazone Decreased digitalis effect. Phenobarbital Decreased digitalis effect. Phenylbutazone Decreased digitalis effect. Potassium supplements Overdosage of either drug may cause severe heartbeat irregularity. Quinidine Increased digitalis effect. Rauwolfia alkaloids Increased digitalis effect. Thyroid hormones Digitalis toxicity. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol None expected. Beverages Caffeine drinks. Irregular heartbeat. Avoid. Cocaine Irregular heartbeat. Avoid. Foods None expected. Marijuana Decreased digitalis effect. Tobacco Irregular heartbeat. Avoid. DIPYRIDAMOLE BRAND NAMES Apo-Dipyridamole Pyridamole Persantine SK-Dipyridamole BASIC INFORMATION Habit forming? No Prescription needed? U.S.: yes - Canada: No Available as generic? Yes Drug class: Coronary vasodilator USES Reduces frequency and intensity of angina attacks. Prevents blood clots after heart surgery. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule - swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid. When to take: 1 hour before meals. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Probably dilates blood vessels to increase oxygen to heart. Prevents platelet clumping, which causes blood clots. Time lapse before drug works: 3 months of continual use. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do Life-threatening: None expected. Common: None expected. Infrequent: * Dizziness, fainting, Discontinue. Call doctor headache. right away. *Red flush, rash, Continue. Call doctor nausea, vomiting, when convenient. cramps, weakness. Rare: None expected. OVERDOSE Symptoms: Decreased blood pressure; weak, rapid pulse; cold, clammy skin; collapse. What to do: *Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. *If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. *See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to dipyridamole. You are recovering from a heart attack. Before you start, consult your doctor: If you have low blood pressure. If you have liver disease. Over age 60: Begin treatment with small doses. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: No proven problems. Consult doctor. Infants and children: Not recommended. Prolonged use: No problems expected. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Avoid if you feel dizzy. Otherwise, no problems expected. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: Drug increases your ability to be active without angina pain. Avoid excessive physical exertion that might injure heart. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticoagulants (oral) Increased anticoagulant effect. Bleeding tendency. Antihypertensives Increased antihypertensive effect. Aspirin Increased dipyridamole effect. Dose may need adjustment. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol May lower blood pressure excessively. Beverages: None expected. Cocaine No proven problems. Foods Decreased dipyridamole absorption unless taken 1 hour before eating. Marijuana Daily use--Decreased dipyridamole effect. Tobacco May decrease dipyridamole Nicotine effect. 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