ÕÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ͸ ³ ³ ³ ---Anti-nausea--- ³ ³ ³ ³ A. Meclizine ³ ³ B. Metoclopramide ³ ³ C. Prochlorperazine ³ ³ D. Trimethobenzamide ³ ³ ³ ÔÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ; MECLIZINE BRAND NAMES Antivert Motion Cure Bonamine Ru-Vert-M Bonine Wehvert BASIC INFORMATION Habit forming? No Prescription needed? U.S.--Tablets: No Liquid: Yes Canada: Yes Available as generic? Yes Drug class: antihistamine, antiemetic. USES Prevents motion sickness. DOSAGE AND USAGE INFORMATION How to take: Tablet--Swallow with liquid or food to lessen stomach irritation. If you can't swallow whole, crumble tablet and chew or take with liquid or food. When to take: 30 minutes to 1 hour before traveling. If you forget a dose: Take as soon as you remember. Wait 4 hours for next dose. What drug does: Reduces sensitivity of nerve endings in inner ear, blocking messages to brain's vomiting center. Time lapse before drug works: 30 to 60 minutes. Don't take with: See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do ____________________________________________________________________ Life-threatening: None expected. Common: Drowsiness. Continue. Call doctor when convenient. Infrequent: Headache, diarrhea or Continue. Call doctor when constipation, fast convenient. heartbeat. Dry mouth, nose, throat. Continue. Tell doctor at next visit. Rare: Rash, hives. Discontinue. Call doctor right away. Restlessness, excitement, Continue. Call doctor when insomnia, blurred vision, convenient. frequent and difficult urination. Appetite loss, nausea. Continue. Tell doctor at next visit. OVERDOSE Symptoms: Drowsiness, confusion, incoordination, stupor, coma, weak pulse, shallow breathing. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. See emergency information. WARNINGS AND PRECAUTIONS Don't take if; You are allergic to meclizine, buclizine or cyclizine. You have taken MAO inhibitors in the past 2 weeks. Before you start, consult your doctor: If you have glaucoma. If you have prostate enlargement. If you have reacted badly to any antihistamine. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons, especially impaired urination from enlarged prostate gland. Pregnancy: Studies inconclusive on harm to unborn child. animal studies show fetal abnormalities. Decide with your doctor whether drug benefits jsutify risk to unborn child. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and Children: No problems expected. Prolonged use: No problems expected. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't fly aircraft. Don't drive until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs. Discontinuing: No problems expected. Others: No problems expected. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug class Combined Effect ____________________________________________________________________ Amphetamines May decrease drowsiness caused by meclizine. Anticholinergics Increased effect of both drugs. Antidepressants (tricyclic) Increased effect of both drugs. MAO inhibitors Increased meclizine effect. Narcotics Increased effect of both drugs. Pain relievers Increased effect of both drugs. Sedatives Increased effect of both drugs. Sleep inducers Increased effect of both drugs. Tranquilizers Increased effect of both drugs. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined Effect ____________________________________________________________________ Alcohol Increased sedation. Avoid. Beverages Caffeine drinks May decrease drowsiness. Cocaine None expected. Foods None expected. Marijuana Increased drowsiness, dry mouth. Tobacco None expected. METOCLOPRAMIDE BRAND NAMES Emex Maxolon Maxeran Reglan BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Antiemetic; dopaminergic blocker USES Releives nausea and vomiting caused by chemotherapy and drug related postoperative factors. Relieves symptoms of esophagitis. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid or food to lessen stomach irritation. When to take: 30 minutes before symptoms expected, up to 4 times a day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Prevents smooth muscle in stomach from relaxing. Affects vomiting center in brain. Time lapse before drug works: 30 to 60 minutes. Don't take with: See interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do ____________________________________________________________________ Life-threatening: None expected. Common: Drowsiness, restlessness. Continue. Call doctor when convenient. Frequent: Rash Continue. Call doctor when convenient. Infrequent: Wheezing, shortness of Discontinue. Call doctor breath. right away. Dizziness; headache; Continue. Call doctor when insomnia; tender, swollen convenient. breasts; increased milk flow. Rare: Constipation, diarrhea, Continue. Call doctor when nausea. convenient. OVERDOSE Symptoms: Severe drowsiness, mental confusion, trembling, seizure, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to procaine, procainamide or metoclopramide. Before you start, consult your doctor: If you have Parkinson's disease. If you have liver or kidney disease. If you have epilepsy. If you have bleeding from gastrointestinal tract or intestinal obstruction. If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: Unknown effect. Infants and children: Adverse reactions more likely to occur than in adults. Prolonged use: Adverse reactions including muscle spasms and trembling hands more likely to occur. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs. Discontinuing: May be unnecessary to finish medicine. Follow doctor's instructions. Others: No problems expected. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect ____________________________________________________________________ Acetaminophen Slow stomach emptying. Bromocriptine Decreased bromocriptine effect. Central nervous system Excess sedation. depressants: antidepressants, antihistamines, muscle relaxants, narcotics, sedatives, sleeping pills, tranquilizers. Digitalis preparations Decreased absorption of digitalis. Levodopa Slow stomach emptying. Phenothiazines Increased chance of muscle spasm and trembling. Tetracycline Slow stomach emptying. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined Effect ____________________________________________________________________ Alcohol Excess sedation. Avoid Beverages Decreased metoclopramide Coffee effect. Cocaine Decreased metoclopramide effect. Foods No problems expected. Marijuana Decreased metoclopramide effect. Tobacco Decreased metoclopramide effect. PROCHLORPERAZINE BRAND NAMES Chlorazine Prochlor-iso Combid Pro-iso Compazine Stemetil Eskatrol BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Tranquilizer, antiemetic (phenothiazine) USES Stops nausea, vomiting Reduces anxiety, agitation DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid or food to lessen stomach irritation. Suppositories--Remove wrapper and moisten suppository with water. Gently insert into rectum, large end first. Drops or liquid--Dilute dose in beverage. When to take: Nervous and mental disorders--Take at the same times each day. Nausea and vomiting--Take as needed, no more often than every 4 hours. If you forget a dose: Nervous and mental disorders--Take up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). Nausea and vomiting--Take as soon as you remember. Wait 4 hours for next dose. What drug does: Suppresses brain's vomiting center. Suppresses brain centers that control abnormal emotions and behavior. Time lapse before drug works: Nausea and vomiting-- 1 hour or less. Nervous and mental disorders--4-6 weeks. Don't take with: Antacid or medicine for diarrhea. Non-prescription drug for cough, cold or allergy. See Interaction column and consult doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do ______________________________________________________________________ Life-threatening: None expected. Common: Muscle spasms of face Discontinue. Seek emergency and neck, unsteady gait. treatment. Restlessness, tremor, Discontinue. Call doctor drowsiness. right away. Decreased sweating, dry Continue. Call doctor when mouth, runny nose, convenient. constipation. Infrequent: Fainting. Discontinue. Seek emergency treatment. Rash. Discontinue. Call doctor right away. Difficult urination, Continue. Call doctor when diminished sex drive, convenient. swollen breasts, menstrual irregularities. Rare: Change in vision, sore Discontinue. Call doctor throat, fever, jaundice. right away. OVERDOSE Symptoms: Stupor, convulsions, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. then give first aid immediately. See Emergency information section. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any phentothiazine. You have a blood or bone-marrow disease. Before you start, consult your doctor: If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. If you have asthma, emphysema or other lung disorder. If you take non-prescription ulcer medicine, asthma medicine or amphetamines. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. More likely to develop involuntary movement of jaws, lips, tongue, chewing. Report this to your doctor immediately. Early treatment can help. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants & children: Don't give to children younger than 2. Prolonged use: May lead to tardive dyskinesia (involuntary movement of jaws, lips, tongue, chewing). Skin & sunlight: May cause rash or intensify sunburn in areas exposed to sun or sunlamp. Skin may remain sensitive for 3 months after discontinuing. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Nervous and mental disorders-Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Nausea and vomiting--May be unnecessary to finish medicine. Follow doctor's instructions. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined effect ______________________________________________________________________ Anticholinergics Increased anticholinergic effect. Antidepressants (tricyclic) Increased prochlorperazine effect. Antihistamines Increased antihistamine 0& à e|More [Y,n,=]? y oºßØxpн½½½¼8 TRIMETHOBENZAMIDE BRAND NAMES Stemetic Tigan Tegamide Tiject-20 Ticon BASIC INFORMATION Habit forming? No Prescription needed? Yes Available as generic? Yes Drug class: Anitemetic USES Reduces nausea and vomiting. DOSAGE AND USAGE INFORMATION How to take: Capsule--Swallow with liquid. If you can't swallow whole, open capsule and take with liquid or food. Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger. When to take: When needed, no more often than label directs. If you forget a dose: Take when you remember. Wait as long as label directs for next dose. What drug does: Possibly blocks nerve impulses to brain's vomiting centers. Time lapse before drug works: 20 to 40 minutes. Don't take with: Non-prescription drugs or drugs in interaction column without consulting doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What to do ____________________________________________________________________ Life-threatening: None expected. Common: None expected. Infrequent: Rash, blurred vision, Discontinue. Call doctor low blood pressure. right away. Dizziness, drowsiness, Continue. Call doctor when headache, diarrhea, muscle convenient. cramps, unusual tiredness. Rare: Seizures, tremor, Discontinue. Call doctor depression, sore throat, right away. fever, repeated vomiting, back pain, jaundice. OVERDOSE Symptoms: Confusion, convulsions, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to trimethobenzamide. You are allergic to local anesthetics and have suppository form. Before you start, consult your doctor: If you have reacted badly to antihistamines. Over age 60: More susceptible to low blood pressure and sedative effects of this drug. Pregnancy: No proven harm to unborn child. Avoid if possible. Breast-feeding: No proven problems. Avoid if possible. Infants and Children: Injectible form not recommended. Avoid during viral infections. Drug may contribute to Reyes' syndrome. Prolonged use: Damages blood-cell production of bone marrow. Causes Parkinson-like symptoms of tremors, rigidity. Skin and sunlight: Possible sun sensitivity. Use caution. Driving, piloting or hazardous work: Use disqualifies you for piloting aircraft. Don't drive until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs. Discontinuing: May be unnecessary to finish medicine. Follow doctor's orders. Other: No problems expected. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect ____________________________________________________________________ Antidepressants Increased sedative effect. Antihistamines Increased sedative effect. Barbiturates Increased effect of both drugs. Belladonna Increased effect of both drugs. Cholinergics Increased effect of both drugs. Mind-altering drugs Increased effect of mind- altering drug. Narcotics Increased sedative effect. Phenothiazines Increased effect of both drugs. Sedatives Increased sedative effect. Sleep inducers Increased effect of sleep inducer. Tranquilizers Increased sedative effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts with Combined effect ____________________________________________________________________ Alcohol Oversedation. Avoid. Beverages None expected. Cocaine None expected. Foods None expected. Marijuana Increased antinausea effect. Tobacco None expected. Downloaded From P-80 International Information Systems 304-744-2253