ÕÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ͸ ³ ³ ³ ------Sedative-Hypnotics------ ³ ³ ³ ³ A. Flurazepam ³ ³ B. Amobarbital ³ ³ C. Chloral Hydrate ³ ³ D. Pentobarbital - Secobarbital ³ ³ E. Temazepam ³ ³ F. Triazolam ³ ³ ³ ÔÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍÍ; FLURAZEPAM BRAND NAMES Apo-Flurazepam Somnal Dalmane Som-Pam Novoflupam BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? Yes Drug class: Tranquilizer (benzodiazepine) USES Treatment for insomnia and tension. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. When to take: At the same time each day, according to instructions on prescription label. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Affects limbic system of brain--part that controls emotions. Induces near-normal sleep pattern. Time lapse before drug works: 30 minutes. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Clumsiness, Continue. Call doctor drowsiness, dizziness. when convenient. Infrequent: Hallucinations, Discontinue. Call doctor confusion, right away. depression, irritability, rash, itch, change in vision. Constipation or Continue. Call doctor diarrhea, nausea, when convenient. vomiting, painful or difficult urination. Rare: Slow heartbeat, Discontinue. Seek difficult breathing. emergency treatment. Mouth, throat Discontinue. Call doctor ulcers, jaundice. right away. OVERDOSE Symptoms: Drowsiness, weakness, tremor, stupor, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any benzodiazepine. You have myasthenia gravis. You are active or recovering alcoholic. Patient is younger than 6 months. Before you start, consult your doctor: If you have liver, kidney or lung disease. If you have diabetes, epilepsy or porphyria. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. May develop agitation, rage or "hangover" effect. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under medical supervision for children older than 6 months. Prolonged use: May impair liver function. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: Hot weather, heavy exercise and profuse sweat may reduce excretion and cause overdose. "Hangover" effect may occur. Blood sugar may rise in diabetics, requiring insulin adjustment. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticonvulsants Change in seizure frequency or severity. Antidepressants Increased sedative effect of both drugs. Antihistamines Increased sedative effect of both drugs. Antihypertensives Excessively low blood pressure. Cimetidine Excess sedation. Disulfiram Increased flurazepam effect. Dronabinol Increased effects of both drugs. Avoid. MAO inhibitors Convulsions, deep sedation, rage. Molindone Increased sedative effect. Narcotics Increased sedative effect of both drugs. Sedatives Increased sedative effect of both drugs. Sleep inducers Increased sedative effect of both drugs. Tranquilizers Increased sedative effect of both drugs. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Heavy sedation. Avoid. Beverages None expected. Cocaine Decreased flurazepam effect. Foods None expected. Marijuana Heavy sedation. Avoid. Tobacco Decreased flurazepam effect. AMOBARBITAL BRAND NAMES Amytal Novamobarb Dexamyl Tuinal Isobec BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? Yes Drug class: Sedative, hypnotic (barbiturate) USES Reduces anxiety or nervous tension (low dose). Relieves insomnia (higher bedtime dose). DOSAGE AND USAGE INFORMATION How to take: Tablet, capsule or liquid--Swallow with food or liquid to lessen stomach irritation. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. When to take: At the same times each day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: May partially block nerve impulses at nerve-cell connections. Time lapse before drug works: 60 minutes. Don't take with: Non-prescription drugs without consulting doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Dizziness, drowsiness, Continue. Call doctor "hangover" effect. when convenient. Infrequent: Rash or hives; Discontinue. Call doctor swollen face, lips, right away. eyelids; sore throat, fever. Depression, Continue. Call doctor confusion, slurred when convenient. speech, nausea, vomiting, joint or muscle pain. Rare: Agitation, slow Discontinue. Call doctor heartbeat, breathing right away. difficulty, jaundice. Unexplained bleeding Continue. Call doctor or bruising. when convenient. OVERDOSE Symptoms: Deep sleep, weak pulse, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any barbiturate. You have porphyria. Before you start, consult your doctor: If you have epilepsy. If you have kidney or liver damage. If you have asthma. If you have anemia. If you have chronic pain. If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Use small doses. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under doctor's supervision. Prolonged use: May cause addiction, anemia, chronic intoxication. May lower body temperature, making exposure to cold temperatures hazardous. Skin and sunlight: May cause rash or intensify sunburn in areas exposed to sun or sunlamp. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: May be unnecessary to finish medicine. Follow doctor's instructions. If you develop withdrawal symptoms of hallucinations, agitation or sleeplessness after discontinuing, call doctor right away. Others: Great potential for abuse. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticoagulants (oral) Decreased anticoagulant effect. Anticonvulsants Changed seizure patterns. Antidepressants Decreased (tricyclics) antidepressant effect. Possible dangerous oversedation. Antidiabetics (oral) Increased amobarbital effect. Antihistamines Dangerous sedation. Avoid. Anti-inflammatory Decreased drugs. anti-inflammatory (non-steroidal) effect. Aspirin Decreased aspirin effect. Beta-adrenergic Decreased effect of blockers beta-adrenergic blocker. Contraceptives (oral) Decreased contraceptive effect. Cortisone drugs Decreased cortisone effect. Digitoxin Decreased digitoxin effect. Doxycycline Decreased doxycycline effect. Dronabinol Increased effects of both drugs. Avoid. Griseofulvin Decreased griseofulvin effect. Indapamide Increased indapamide effect. MAO inhibitors Increased amobarbital effect. Mind-altering drugs Dangerous sedation. Avoid. Narcotics Dangerous sedation. Avoid. Pain relievers Dangerous sedation. Avoid. Sedatives Dangerous sedation. Avoid. Sleep inducers Dangerous sedation. Avoid. Tranquilizers Dangerous sedation. Avoid. Valproic acid Increased amobarbital effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Possible fatal oversedation. Avoid. Beverages None expected. Cocaine Decreased amobarbital effect. Foods None expected. Marijuana Excessive sedation. Avoid. Tobacco None expected. CHLORAL HYDRATE BRAND NAMES Aquachloral Novochlorhydrate Aquachloral Supprettes Oradrate Colidrate SK-Chloral Hydrate Noctec BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? Yes Drug class: Hypnotic USES Reduces anxiety. Relieves insomnia. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with milk or food to lessen stomach irritation. Drops--Dilute dose in beverage before swallowing. Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger. When to take: At the same time each day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Affects brain centers that control wakefulness and alertness. Time lapse before drug works: 30 to 60 minutes. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Nausea, stomach Discontinue. Call doctor pain, vomiting. right away. Infrequent: "Hangover" effect, Continue. Call doctor clumsiness or when convenient. unsteadiness, drowsiness, dizziness, lightheadedness. Rare: Hallucinations, Discontinue. Call doctor agitation, confusion. right away. Hives, rash. Continue. Call doctor when convenient. OVERDOSE Symptoms: Confusion, weakness, breathing difficulty, stagger, slow or irregular heartbeat. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not brething, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to chloral hydrate. Before you start, consult your doctor: If you have had liver, kidney or heart trouble. If you are prone to stomach upsets (if medicine is in oral form). If you have colitis or a rectal inflammation (if medicine is in suppository form). Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. More likely to have "hangover" effect. Pregnancy: Risk to unborn child outweighs drug benefits. Unborn child may become addicted to drug. Don't use. Breast-feeding: Drug filters into milk. May harm child. Avoid. Infants and children: Use only under medical supervision. Prolonged use: Addiction and possible kidney damage. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes, such as antihistamines, tranquilizers, sedatives, pain medicine, narcotics and mind-altering drugs. Discontinuing: Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment. Others: Frequent kidney-function tests recommended when drug is used for a long time. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticoagulants Possible hemorrhaging. Antidepressants Increased chloral hydrate effect. Antihistamines Increased chloral hydrate effect. Cortisone drugs Decreased cortisone effect. MAO inhibitors Increased chloral hydrate effect. Mind-altering drugs Increased chloral hydrate effect. Molindone Increased tranquilizer effect. Narcotics Increased chloral hydrate effect. Pain relievers Increased chloral hydrate effect. Phenothiazines Increased chloral hydrate effect. Sedatives Increased chloral hydrate effect. Sleep inducers Increased chloral hydrate effect. Tranquilizers Increased chloral hydrate effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Increased sedative effect of both. Avoid. Beverages None expected. Cocaine Decreased chloral hydrate effect. Avoid. Foods None expected. Marijuana May severely impair mental and physical functioning. Avoid. Tobacco None expected. PENTOBARBITAL AND SECOBARBITAL BRAND NAMES - PENTOBARBITAL Carbrital Pentogen Nembutal Quless Nova-Rectal Wigraine-PB Novopentobarb BRAND NAMES - SECOBARBITAL Novo Secobarb Seral Secogen Tuinal Seconal BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? Yes Drug class: Sedative, hypnotic (barbiturate) USES Reduces anxiety or nervous tension (low dose). Relieves insomnia (higher bedtime dose). DOSAGE AND USAGE INFORMATION How to take: Tablet, capsule or liquid--Swallow with food or liquid to lessen stomach irritation. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. Suppositories--Remove wrapper and moisten suppository with water. Gently insert larger end into rectum. Push well into rectum with finger. When to take: At the same times each day. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: May partially block nerve impulses at nerve-cell connections. Time lapse before drug works: 60 minutes. Don't take with: Non-prescription drugs without consulting doctor. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Dizziness, drowsiness, Continue. Call doctor "hangover" effect. when convenient. Infrequent: Rash or hives; face, Discontinue. Call doctor lip seelling; swollen right away. eyelids; sore throat, fever. Depression, Continue. Call doctor confusion, slurred when convenient. speech, diarrhea, nausea, vomiting, joint or muscle pain. Rare: Agitation, slow Discontinue. Call doctor heartbeat, difficult right away. breathing, jaundice. Unexplained bleeding Continue. Call doctor or bruising. when convenient. OVERDOSE Symptoms: Deep sleep, weak pulse, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any barbiturate. You have porphyria. Before you start, consult your doctor: If you have epilepsy. If you have kidney or liver damage. If you have asthma. If you have anemia. If you have chronic pain. If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. Use small doses. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under doctor's supervision. Prolonged use: May cause addiction, anemia, chronic intoxication. May lower body temperature, making exposure to cold temperatures hazardous. Skin and sunlight: May cause rash or intensify sunburn in areas exposed to sun or sunlamp. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: May be unnecessary to finish medicine. Follow doctor's instrucitons. If you develop withdrawal symptoms of hallucinations, agitation or sleeplessness after discontinuing, call doctor right away. Others: Great potential for abuse. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticoagulants (oral) Decreased anticoagulant effect. Anticonvulsants Changed seizure pattern. Antidepressants Decreased antidepressant (tricyclics) effect. Possible dangerous oversedation. Antidiabetics Increased pentobarbital (oral) effect. Antihistamines Dangerous sedation. Avoid Anti-inflammatory Decreased drugs (non-steroidal) anti-inflammatory effect. Aspirin Decreased aspirin effect. Beta-adrenergic Decreased effect of blockers beta-adrenergic blocker. Contraceptives Decreased (oral) contraceptive effect. Cortisone drugs Decreased cortisone effect. Digitoxin Decreased digitoxin effect. Doxycycline Decreased dosycycline effect. Dronabinol Increased effects of both drugs. Avoid. Griseofulvin Decreased griseofulvin effect. Indapamide Increased indapamide effect. MAO inhibitors Increased pentobarbital effect. Mind-altering drugs Dangerous sedation. Avoid. Molindone Increased sedative effect. Narcotics Dangerous sedation. Avoid. Pain relievers Dangerous sedation. Avoid. Sedatives Dangerous sedation. Avoid. Sleep inducers Dangerous sedation. Avoid. Tranquilizers Dangerous sedation. Avoid. Valproic acid Increased pentobarbital effect. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Possible fatal oversedation. Avoid. Beverages None expected. Cocaine Decreased pentobarbital effect. Foods None expected. Marijuana Excessive sedation. Avoid. Tobacco None expected. TEMAZEPAM BRAND NAMES Restoril BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? Yes Drug class: Tranquilizer (benzodiazepine) USES Treatment for insomnia. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. When to take: At the same time each day, according to instructions on prescription label. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Affects limbic system of brain--part that controls emotions. Induces near-normal sleep pattern. Time lapse before drug works: 30 minutes. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Clumsiness, Continue. Call doctor drowsiness, dizziness. when convenient. Infrequent: Hallucinations, Discontinue. Call doctor confusion, depression, right away. irritability, rash itchy skin, change in vision. Constipation or Continue. Call doctor diarrhea, nausea, when convenient. vomiting, difficult urination. Rare: Slow heartbeat, Discontinue. Seek difficult breathing. emergency treatment. Mouth or throat Discontinue. Call doctor ulcers, jaundice. right away. OVERDOSE Symptoms: Drowsiness, weakness, tremor, stupor, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not breathing, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any benzodiazepine. You have myasthenia gravis. You are active or recovering alcoholic. Patient is younger than 6 months. Before you start, consult your doctor: If you have liver, kidney or lung disease. If you have diabetes, epilepsy or porphyria. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. May develop agitation, rage or "hangover" effect. Pregnancy: Risk to unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on maintaining milk supply. Infants and children: Use only under medical supervision for children older than 6 months. Prolonged use: May impair liver function. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Don't discontinue without doctor's advice until you complete prescribed dose, even though symptoms diminish or disappear. Others: Hot weather, heavy exercise and profuse sweat may reduce excretion and cause overdose. Blood sugar may rise in diabetics, requiring insulin adjustment. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticonvulsants Change in seizure frequency or severity. Antidepressants Increased sedative effect of both drugs. Antihistamines Increased sedative effect of both drugs. Antihypertensives Excessively low blood pressure. Cimetidine Excess sedation. Disulfiram Increased temazepam effect. Dronabinol Increased effects of both drugs. Avoid. MAO inhibitors Convilsions, deep sedation, rage. Molindone Increased sedative effect. Narcotics Increased sedative effect of both drugs. Sedatives Increased sedative effect of both drugs. Tranquilizers Increased sedative effect of both drugs. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interactis With Combined Effect Alcohol Heave sedation. Avoid. Beverages None expected. Cocaine Decreased temazepam effect. Foods None expected. Marijuana Heavy sedation. Avoid. Tobacco Decreased temazepam effect. TRIAZOLAM BRAND NAMES Halcion BASIC INFORMATION Habit forming? Yes Prescription needed? Yes Available as generic? No Drug class: Tranquilizer (benzodiazepine) USES Treatment of insomnia. Not recommended for more than 2 weeks maximum. DOSAGE AND USAGE INFORMATION How to take: Tablet or capsule--Swallow with liquid. If you can't swallow whole, crumble tablet or open capsule and take with liquid or food. When to take: At the same time each day, according to instructions on prescription label. If you forget a dose: Take as soon as you remember up to 2 hours late. If more than 2 hours, wait for next scheduled dose (don't double this dose). What drug does: Affects limbic system, the part of the brain that controls emotions. Time lapse before drug works: 2 hours. May take 6 weeks for full benefit. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS Symptoms What To Do Life-threatening: None expected. Common: Clumsiness, Continue. Call doctor drowsiness, dizziness. when convenient. Infrequent: Hallucinations, Discontinue. Call doctor confusion, depression, right away. irratibility, rash, itchy skin, change in vision. Constipation or Continue. Call doctor diarrhea, nausea, when convenient. vomiting, difficult urination. Rare: Slow heartbeat, Discontinue. Seek difficult breathing. emergency treatment. Mouth or throat Discontinue. Call doctor ulcers, jaundice. right away. OVERDOSE Symptoms: Drowsiness, weakness, tremor, stupor, coma. What to do: Dial 0 (operator) or 911 (emergency) for an ambulance or medical help. Then give first aid immediately. If patient is unconscious and not brething, give mouth-to-mouth breathing. If there is no heartbeat, use cardiac massage and mouth-to-mouth breathing (CPR). Don't try to make patient vomit. If you can't get help quickly, take patient to nearest emergency facility. See emergency information. WARNINGS AND PRECAUTIONS Don't take if: You are allergic to any benzodiazepine. You have myasthenia gravis. You are active or recovering alcoholic. Patient is younger than 6 months. Before you start, consult your doctor: If you have liver, kidney or lung disease. If you have diabetes, epilepsy or porphyria. If you will have surgery within 2 months, including dental surgery, requiring general or spinal anesthesia. Over age 60: Adverse reactions and side effects may be more frequent and severe than in younger persons. You need smaller doses for shorter periods of time. May develop agitation, rage or "hangover" effect. Pregnancy: Risk ot unborn child outweighs drug benefits. Don't use. Breast-feeding: Drug passes into milk. Avoid drug or discontinue nursing until you finish medicine. Consult doctor for advice on mainataining milk supply. Infants and children: Use only under medical supervision for children older than 6 months. Prolonged use: May impair liver function. Skin and sunlight: No problems expected. Driving, piloting or hazardous work: Don't drive or pilot aircraft until you learn how medicine affects you. Don't work around dangerous machinery. Don't climb ladders or work in high places. Danger increases if you drink alcohol or take medicine affecting alertness and reflexes. Discontinuing: Don't discontinue without consulting doctor. Dose may require gradual reduction if you have taken drug for a long time. Doses of other drugs may also require adjustment. Others: Hot weather, heavy exercise and profuse sweat may reduce excretion and cause overdose. Blood sugar may rise in diabetics, requiring insulin adjustment. POSSIBLE INTERACTION WITH OTHER DRUGS Generic Name or Drug Class Combined Effect Anticonvulsants Change in seizure frequency or severity. Antidepressants Increased sedative effect of both drugs. Antihistamines Increased sedative effect of both drugs. Antihypertensives Excessively low blood pressure. Cimetidine Excess sedation. Disulfiram Increased triazolam effect. Dronabinol Increased effects of both drugs. Avoid. MAO inhibitors Convulsions, deep sedation, rage. Molindone Increased sedative effect. Narcotics Increased sedative effect of both drugs. Sedatives Increased sedative effect of both drugs. Sleep inducers Increased sedative effect of both drugs. Tranquilizers Increased sedative effect of both drugs. POSSIBLE INTERACTION WITH OTHER SUBSTANCES Interacts With Combined Effect Alcohol Heavy sedation. Avoid. Beverages None expected. Cocaine Decreased traizolam effect. Foods None expected. Marijuana Heavy sedation. Avoid. Tobacco Decreased triazolam effect. Downloaded From P-80 International Information Systems 304-744-2253