1           R  @ H H H H H                                                                   I                              Synthesis of Methylaminorex: US Patent #3,161,650

	A mixture of 300cc of methanol and 50cc of water is used to dissolve
about 35g (.187 mole) of 2-amino-1-phenyl-1-propanol hydrochloride and 16.9g
(0.411 mole) of sodium acetate.  To this solution there is added a
solution of 21.6g (0.206 mole) of cyanogen bromide in 200cc of methanol.
The mixture is stirred for one half hour at room temperature and then
concentrated under vacuum to remove the methanol.  The residue is taken
up in water and the resulting aqueous solution is made strongly basic with
10% sodium hydroxide and then saturated with potassium carbonate.  The
resulting precipitate of the crude product is filtered off, washed twice
with water and dried.  The yield of 2-amino-4-methyl-5-phenyloxazoline if
12g (m. 155.5-158.5 degrees).  After recrystallization from benzene, the
product melts at 154.5-156 degrees.


<<<>>>
--------------------------------------------------------------------
It is available in all larger urban areas, but is not common.  You need to
be pretty well connected to get it.

Boiling point is very low.  You can smoke it by placing about 10 mg
on aluminum foil, and holding a lighter under the foil to warm it.
It vaporizes into a white cloud, and you suck the smoke through a tube
or something to help catch all the smoke.  It comes in a white powder,
and looks similar to good white heroin.  I think it would be hard
to aldulterate, unless you adulterated it with something that also
vaporized very easily.  Ie, if you aldulterated it with sugar, the
Aminorex would evaporate first, then the sugar would just burn, and
you would be aware that you got burned.

Not many side effects.  If you do a large amount for several days
you can get diareaha.  Nothing too severe though.  A bit of dry mouth
is common after smoking it.  I also started to get a sore throat
after smoking for a solid week.

I developed somewhat of a tolerance after 4-5 days of constant use.
A few days off, and the tolerance seemed to disappear.  My brain
was so clear when I used this, that I came up with answers to
problems that had been bugging me for months.  This stuff makes
your brain work at 100% efficiency and doubles processor speed.
It makes you feel (and probably actually does) like your IQ jumped
quite a bit.  It is kind of a bummer not doing it at the moment
because my brain feels so slow now in comparison to before.  A gram
would last you anywhere from a week to a month depending on how much
you do.  I estimate one hit at 10 mg, so a gram would give you 100
hits.  2 hits makes you feel alert.  5 hits makes you euphoric and
will let you stay up all night long without feeling the leat bit
tired.  Sleep will never even occur to you.  Do 2 more hits in
the morning before work, and you will never miss the sleep from
the night before.  As a matter of fact, you will feel better than
if you had skipped the drug and slept all night!
-------------------------------------------------------------------
me:  This sounds so great, that it amazes me that it has not become
a _big_ deal, as in _the_ drug of choice for everybody in the world,
or at least everybody who has ever tried it.   $75/g wouldn't be a bad
price either, but I'm sure it would go up if it becomes popular.  (...got
damn,  why isn't it already???)

Hard to make?   That could be it.   Can somebody post the Methylamorex
(sp?) abstracts and any stuff they have.  I want to find out about
this chemical.   What name will it be under in Mercks?

It should be fairly easy to make. At 1986 Rainbow Gathering in
Pennsylvania some people combined 4-methyl aminorex with LSD (stoopid!)
and had bad experiences, which gave the drug a bad reputation.
Popularity increase all over the world is predicted in the future. It was
put in Schedule I on October 15, 1987 after a seizure of a high
production lab in Florida. A fatality involving Euphoria has been
reported (Journal of Forensic Sciences 33:2 March 1988 pp 549-553),
allegedly after daily use for several months in combination with
phenobarbital. In post-mortem analysis the concentration of U4Euh in
blood was found to be 21.3 mg/L (!). The guy who has been giving away
Euphoria and info about it, The Friendly Stranger (you know those old
'Beware!..' marijuana scare posters), seems to know his business pretty
well (Psychedelic M&E vol 4).

When ingested orally the usual dosage is 15-30 mg as the free base
(18-36 mg as the HCl), onset of effects 1-2 hours, duration 14-16 hours.
"Qualitatively, the experience is similar to a long-lasting MDMA intoxication
superimposed with methamphetamine, with the added benefits of easy
verbalization, free association, integration and elaboration of previous
insights.." - The New Age Chemist, PM&E 4. Transient somatic effects:
increased respiration, tachycardia, tremors, perspiration, increased blood
pressure, intraocular pressure, blurred visionand tightness in the chest.
Increased body and breath odor.

Oh well.. Here are those references:

J Medicinal Chem 6,266 (1963)
Belgian Patent 628,803 June 16 1963
French Patent M2448
US Patents 3,161,650 Dec 15 1964 3,278,382 Oct 11 1966
Archives Int Pharmacodyn Ther 164(2), 412-18 (1966)
J Pharmacology and Experimental Therapeutics 140:367-374 1963
Ibid. 141:180-184 1964
J Clinical Pharmacology 7:296-302 1967
Science 218(457) 487-490 1982
Annual Review of Med Chem 51-58 1965, 44-47 1966
52 Federal Registry (FR) 30174
52 FR 38225

The stuff is called 4-methyl aminorex or 4-methyl-5-phenyl-2-amino-oxazoline.
CAS registry numbers: cis (racemic)-[29493-77-4] trans (+)-[27780-30-9].


<<<>>>

<<<>>>

Through experience I have compiled the following tips for ppl wanting
to do the CAT  synthesis. It isn't hard, but the posted synthesis cannot
lead to good results becuase of certain ommisions. I don't know if these
were omitted deliberately as to stop non-chemists from completing it or
whether the author of the original article just forgot. In any case, here
are some things you should be aware of.

1) When dissolving the ephedrine don't use 'as little amount of water as
possible' as the instructions say. This will lead to a very thick reaction
mixture. When extracting with naphta this thickness will prevent separation
of layers. The naphta will stay in suspension and the naphta that does
separate will not contain high amounts of CAT. This leads to unacceptably
low yields. Use about 10 ml. of water per gram of dissolved ephedrine. Do
not use tap-water, get de-mineralised water. Trace amounts of minerals will
inhibit the reaction.
2) Add the sulphuric acid *very slowly*. If you don't, local concentrations
will get too high, causing the ephedrine to break down. Stir well while
adding the H2SO4.
3) This is the most important omission: The whole reaction mixture has to
be cooled while basifying it with Sodium hydroxyde. The heat developed
during this stage will cause practicaly all the CAT to break down if you
don't. The best way to cool it is as follows: Place the reaction mixture
in an ice-bath 10 minutes before adding the NaOH. Then, just before adding
the NaOH, chuck a handfull of salt over the ice (NOT in the reaction
mixture!)  This will cause the temperature to drop another couple of
degrees, ensuring a good cooling.
4) Use a magnetic stirring device troughout the whole procedure.
5) When extracting the CAT from the naphta with the HCl use a 20%
solution in stead of the mentioned 10% (approx.)
6) When evaporating the excess amounts of water (preferably under vacuum)
do not let the temperature exceed 70 degrees C. (approx 150 F.) Again, the
high temperature would cause the CAT to disintegrate. :-(

If you follow these additional comments, you should be able to have success!

The anonymous chemist.

 after daily use for several months in combina   R  w       R                                                                                                     B               J        h      F               R           
  N      !  e          \          M      	   	  P	  	  	  
X-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-X
 Another file downloaded from:                                NIRVANAnet(tm)

 &TOTSE                510/935-5845   Walnut Creek, CA         Taipan Enigma
 Burn This Flag        408/363-9766       San Jose, CA                Zardoz
 realitycheck          415/648-9489  San Francisco, CA    Poindexter Fortran
 Phallicide            408/899-0235       Monterey, CA          Reclinerhead
 Governed Anarchy      510/226-6656        Fremont, CA             Eightball
 New Dork Sublime      805/823-1346      Tehachapi, CA               Biffnix
 The Ether Room        510/228-1146       Martinez, CA Tiny Little Super Guy
 Lies Unlimited        801/278-2699 Salt Lake City, UT            Mick Freen
 The Shrine            206/793-3465         Monroe, WA               Rif Raf
 Atomic Books          410/669-4179      Baltimore, MD               Baywolf
 Sea of Noise          203/886-1441        Norwich, CT             Mr. Noise
 The Floating Pancreas 305/424-0266 Ft. Lauderdale, FL     Majestic Cockster
 The Dojo              713/436-1795       Pearland, TX               Yojimbo
 Frayed Ends of Sanity 503/965-6747     Cloverdale, OR              Flatline

                          "Raw Data for Raw Nerves"
X-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-=-X
