Requirements

System requirements

Memory: Well, this mostly depends on your input-data. To process reasonable sized pages, about 300K of free ram should be enough. For large pages and projects using loads of documents, this can increase to 1MB or even more, so your machine should have at least 2MB of memory.
Stack: A stack value of12KB usually should be sufficient; at least, this worked for these documents.
AmigaOS and CPU: Basically, it works on an A2000 with AmigaOS 2.04 and a plain 68000, but as this isn't much fun, the binaries are compiled for 68020. As hsc is not one of the fastest, a 68040 is recommended.

Knowledge requirements

hsc is not a tool for beginners. It does not make html easier. It only makes it a bit less painful and brain-damaged - that's all. Therefor, these documents assume that you are already familiar with html. There exist several sources for beginners, and this won't be page #1876545 which lists these sources (But I'm frightened, the section about related stuff has degenerated to one of these pages..).

If you also want to utilize the project management capabilities, you should also know how to work with make and write your own Makefiles.

For several other advanced topics, it is required to have some experiences with any programming language. Rexx is fully sufficient for these task, and most examples and some supporting stuff is written in this language.

As hsc is a CLI-only tool, any knowledge of how to work with mouse and icons is not required.